|  Seattle Sounders FC – Sporting Kansas City | 2-1 |
|  New York Red Bulls – St. Louis City SC | 0-3 |
|  Columbus Crew – Inter Miami CF | 2-1 |
|  Los Angeles Galaxy – Colorado Rapids | 3-2 |
|  San Jose Earthquakes – Portland Timbers | 3-1 |
|  Vancouver Whitecaps – DC United | 3-3 |
|  Real Salt Lake – New England Revolution | 3-0 |
|  Austin FC – San Diego FC | 3-3 |
|  FC Dallas – Los Angeles FC | 1-0 |
|  Houston Dynamo – Sporting Kansas City | 0-2 |
|  Nashville SC – Toronto FC | 2-0 |
| Seattle Sounders FC – Minnesota United FC | 3-1 |
|  Atlanta United – New York City FC | 2-2 |
|  CF Montréal – FC Cincinnati | 3-1 |
|  Charlotte FC – Chicago Fire | 0-1 |
|  Philadelphia Union – Orlando City SC | 4-2 |
| Seattle Sounders FC – Real Salt Lake | 2-0 |
| Inter Miami CF – San Diego FC | 2-2 |
| Portland Timbers – Atlanta United | 0-1 |
| Colorado Rapids – Seattle Sounders FC | 3-3 |
| Nashville SC – Chicago Fire | 3-0 |
| Real Salt Lake – Vancouver Whitecaps | 0-3 |
| FC Dallas – Austin FC | 0-0 |
| Houston Dynamo – FC Cincinnati | 2-2 |
| Minnesota United FC – Los Angeles Galaxy | 2-3 |
| Sporting Kansas City – Philadelphia Union | 3-4 |
| St. Louis City SC – Toronto FC | 3-1 |
| CF Montréal – Columbus Crew | 0-2 |
| DC United – Charlotte FC | 1-2 |
| New England Revolution – Orlando City SC | 4-2 |
| San Jose Earthquakes – Los Angeles FC | 2-2 |
| New York City FC – New York Red Bulls | 0-1 |
| San Diego FC – Philadelphia Union | 0-5 |
| Vancouver Whitecaps – Austin FC | 1-2 |
| Chicago Fire – New England Revolution | 1-2 |
| Los Angeles Galaxy – Seattle Sounders FC | 1-1 |
| San Jose Earthquakes – Houston Dynamo | 1-0 |
| Colorado Rapids – CF Montréal | 1-0 |
| Real Salt Lake – New York City FC | 0-2 |
| FC Dallas – Portland Timbers | 2-1 |
| Sporting Kansas City – Los Angeles FC | 3-1 |
| St. Louis City SC – Minnesota United FC | 4-2 |
| Columbus Crew – New York Red Bulls | 0-1 |
| DC United – Atlanta United | 0-0 |
| FC Cincinnati – Charlotte FC | 3-3 |
| Inter Miami CF – Nashville SC | 2-2 |
| Orlando City SC – Toronto FC | 3-0 |
| Los Angeles FC – New York Red Bulls | 2-0 |
| Portland Timbers – St. Louis City SC | 2-2 |
| San Diego FC – San Jose Earthquakes | 2-3 |
| Vancouver Whitecaps – Los Angeles Galaxy | 3-0 |
| Austin FC – Colorado Rapids | 1-1 |
| Chicago Fire – Inter Miami CF | 1-1 |
| Houston Dynamo – Real Salt Lake | 2-1 |
| Minnesota United FC – FC Dallas | 1-2 |
| New York City FC – New England Revolution | 1-2 |
| Atlanta United – Orlando City SC | 2-3 |
| CF Montréal – Charlotte FC | 1-2 |
| DC United – Columbus Crew | 2-1 |
| Philadelphia Union – FC Cincinnati | 5-0 |
| Toronto FC – Nashville SC | 2-1 |
| Portland Timbers – Minnesota United FC | 5-4 |
| Vancouver Whitecaps – St. Louis City SC | 1-3 |
| Los Angeles Galaxy – New England Revolution | 2-1 |
| Real Salt Lake – Los Angeles FC | 2-2 |
| Austin FC – San Jose Earthquakes | 1-1 |
| FC Dallas – Sporting Kansas City | 4-3 |
| Seattle Sounders FC – New York Red Bulls | 0-0 |
| Charlotte FC – Houston Dynamo | 0-0 |
| Columbus Crew – Colorado Rapids | 3-0 |
| Inter Miami CF – Atlanta United | 2-2 |
| Orlando City SC – San Diego FC | 1-0 |
| Philadelphia Union – CF Montréal | 2-0 |
| Toronto FC – Chicago Fire | 4-4 |
| New York City FC – Nashville SC | 0-0 |
| St. Louis City SC – FC Dallas | 3-3 |
| Portland Timbers – Austin FC | 1-2 |
| San Diego FC – Los Angeles Galaxy | 3-1 |
| Colorado Rapids – Real Salt Lake | 1-0 |
| Houston Dynamo – San Jose Earthquakes | 0-0 |
| Minnesota United FC – Orlando City SC | 3-3 |
| Nashville SC – FC Cincinnati | 4-0 |
| Sporting Kansas City – Vancouver Whitecaps | 0-3 |
| Atlanta United – Charlotte FC | 0-2 |
| Columbus Crew – New England Revolution | 1-3 |
| DC United – Los Angeles FC | 0-0 |
| Inter Miami CF – CF Montréal | 7-1 |
| New York Red Bulls – Philadelphia Union | 1-3 |
| Toronto FC – New York City FC | 1-1 |
| Seattle Sounders FC – Chicago Fire | 2-2 |
| Atlanta United – Sporting Kansas City | 2-1 |
| New England Revolution – New York City FC | 1-1 |
| Los Angeles FC – Portland Timbers | 1-1 |
| San Diego FC – Colorado Rapids | 3-0 |
| San Jose Earthquakes – Minnesota United FC | 1-5 |
| Vancouver Whitecaps – FC Dallas | 5-0 |
| Austin FC – Philadelphia Union | 1-1 |
| Nashville SC – Columbus Crew | 3-2 |
| St. Louis City SC – Houston Dynamo | 2-1 |
| CF Montréal – Los Angeles Galaxy | 2-2 |
